Neuronal Representation of Locomotion During Motivated Behavior in the Mouse Anterior Cingulate Cortex

The anterior cingulate cortex (ACC) is located within the dorsomedial prefrontal (PFC), and processes facilitates goal-directed behaviors relating to emotion, reward, motor control. However, it unclear how ACC neurons dynamically encode motivated behavior during locomotion. In this study, we examined information for locomotion behavioral outcomes temporally represented by individual ensembles of in mice a self-paced locomotor reward-based task. By recording analyzing activity with microdrive tetrode array while mouse performed task, found that more than two-fifths showed phasic or reward behavior. Some these significant differences their firing rate depending on outcome. Furthermore, applying demixed principal component analysis, population was decomposed into components representing previous/future These results indicated integrate inputs behaviors.